FIGURE

Fig. 7

ID

ZDB-FIG-240109-54

Publication

Tian et al., 2024 - WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

SIRT1 regulates SMARCA5 expression during adipogenesis in hMSCs and zebrafish models. a–g qRT-PCR analysis of SIRT family (SIRT1-7) on day 5 during adipogenesis (N = 3 biological replicates). h–n qRT-PCR analysis of sirt1-7 at 2 dpf, 4 dpf, and 14 dpf in zebrafish (N = 3 biological replicates). o, p qRT-PCR analysis of PPARγ (o) and CEBPα (p) among WT, WRN KO, and WRN KO (SIRT1) on day 5 during adipogenesis (N = 3 biological replicates). q, r qRT-PCR analysis of pparγ (q) and cebpα (r) among wildtype, wrn^−/− mutant zebrafish, wrn^−/− mutant zebrafish (SIRT1) (N = 3 biological replicates). s qRT-PCR analysis of SMARCA5 among WT, WRN KO, and WRN KO (SIRT1) on day 5 during adipogenesis (N = 3 biological replicates). t qRT-PCR analysis of smarca5 among wildtype, wrn^−/− mutant zebrafish, wrn^−/− mutant zebrafish (SIRT1) (N = 3 biological replicates). Data are presented as the mean ± S.D. Statistical analysis was performed using two-tailed unpaired Student’s t-test. *P < 0.05, **P < 0.01, ***P < 0.001

Expression Data

Genes:	cebpa pparg sirt1 sirt2 sirt3 sirt4 sirt5 sirt6 sirt7 smarca5
Fish:	WT wrn^{sa34829/sa34829}
Anatomical Term:	whole organism
Stage Range:	Long-pec to Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Biosci.