Gene
sirt4
- ID
- ZDB-GENE-041010-65
- Name
- sirtuin 4
- Symbol
- sirt4 Nomenclature History
- Previous Names
-
- im:7139453
- zgc:103539 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have several functions, including NAD+ binding activity; NAD-dependent protein deacetylase activity; and zinc ion binding activity. Predicted to be involved in protein ADP-ribosylation. Predicted to localize to mitochondrial matrix. Is expressed in liver and retina. Orthologous to human SIRT4 (sirtuin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139453 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026590 | Sirtuin family, catalytic core domain |
| Family | IPR003000 | Sirtuin family |
| Family | IPR026587 | Sirtuin, class II |
| Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
| Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin, class II | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QHM6
|
310 | ||||||
|
UniProtKB:Q5XJ86
|
310 |
Interactions and Pathways
No data available
Plasmids
No data available