Gene
sirt2
- ID
- ZDB-GENE-030131-1028
- Name
- sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
- Symbol
- sirt2 Nomenclature History
- Previous Names
-
- wu:fb57d05
- zgc:77003
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have NAD+ binding activity; protein deacetylase activity; and transcription factor binding activity. Involved in cilium assembly and negative regulation of angiogenesis. Predicted to localize to several cellular components, including Schmidt-Lanterman incisure; main axon; and microtubule cytoskeleton. Is expressed in liver and retina. Orthologous to human SIRT2 (sirtuin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55966 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026590 | Sirtuin family, catalytic core domain |
| Family | IPR003000 | Sirtuin family |
| Family | IPR017328 | Sirtuin, class I |
| Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
| Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin, class I | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ASG7
|
343 | ||||||
|
UniProtKB:Q7ZVK3
|
379 |
Interactions and Pathways
No data available
Plasmids
No data available