Gene
sirt1
- ID
- ZDB-GENE-070801-2
- Name
- sirtuin 1
- Symbol
- sirt1 Nomenclature History
- Previous Names
-
- im:7148963
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have several functions, including NAD+ binding activity; p53 binding activity; and transcription corepressor activity. Involved in cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; and regulation of gliogenesis. Predicted to localize to chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Is expressed in female organism; liver; male organism; and retina. Orthologous to human SIRT1 (sirtuin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148963 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR026590 | Sirtuin family, catalytic core domain |
| Family | IPR003000 | Sirtuin family |
| Family | IPR050134 | NAD-dependent sirtuin protein deacylases |
| Homologous_superfamily | IPR026591 | Sirtuin, catalytic core small domain superfamily |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin, catalytic core small domain superfamily | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BKA6
|
695 | |||||
|
UniProtKB:E7F8W3
|
710 |
- Genome Browsers
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-sirt1 | Rabbit |
|
Aviva Systems Biology
|
2 | |||
| Ab2-sirt1 | polyclonal | Rabbit |
|
Sigma-Aldrich
|
1 |
Plasmids
No data available