Gene
cebpa
- ID
- ZDB-GENE-020111-2
- Name
- CCAAT enhancer binding protein alpha
- Symbol
- cebpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in hematopoietic stem cell migration; hemopoiesis; and liver development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; mesoderm; and yolk syncytial layer. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 58 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1062 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
acute myeloid leukemia | Alliance | ?Leukemia, acute myeloid | 601626 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | CCAAT/enhancer-binding protein C/EBP | CCAAT/enhancer-binding protein, chordates |
---|---|---|---|---|---|
UniProtKB:Q8UVZ1
|
288 |
Interactions and Pathways
No data available
Plasmids