FIGURE

Fig. S4

ID

ZDB-FIG-080516-26

Publication

Shin et al., 2008 - Multiple roles for Med12 in vertebrate endoderm development

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Fig. S4

Med12 regulates anterior sox17 expression in endodermal cells during gastrulation. Wild-type and med12^s432 mutants were analyzed at 60% (A–B′) and 90% (C–E′) epiboly for bon (A, A′), gata5 (B, B′), sox17 (C, C′), foxa2 (D, D′), and cas (E, E′) expression. White dashed lines in C and C′ surround a subset of sox17-positive cells in the anterior region. Note that, in med12^s432 mutants, many of these cells are missing, whereas other early endodermal markers show comparable expression in wild-type and mutants. After in situ hybridization, the embryos were genotyped to unambiguously identify the mutants. A–B′ are animal pole views; C–E′ are dorsal views, anterior to the top.

Expression Data

Genes:	foxa2 gata5 mixl1 sox17 sox32
Fish:	WT med12^s432/s432
Anatomical Terms:	endoderm presumptive endoderm
Stage Range:	Shield to 90%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	med12^s432/s432
Observed In:	endoderm development
Stage:	90%-epiboly

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.