FIGURE

Fig. 2

ID

ZDB-FIG-080516-17

Publication

Shin et al., 2008 - Multiple roles for Med12 in vertebrate endoderm development

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Fig. 2

shr is required for dorsal pancreas development. Confocal projections of wild-type and shr^s435 mutant embryos at 34 (A–D′) and 56 (E–H′) hpf stained for Islet (red, A, A′, E, E′), Insulin (green, B, B′, F, F′), Glucagon (red, C, C′, G, G′), and Somatostatin (green, D, D′, H, H′) expression. The pancreatic expression of Islet and Insulin appears unaffected in shr^s435 mutants at 34 and 56 hpf (A′, B′, E′, F′). The expression of Somatostatin appears reduced (D′) and that of Glucagon almost completely absent (C′) in shr^s435 mutants at 34 hpf, but restored to wild-type levels by 56 hpf (G′, H′). All images are ventral views, anterior to the top.

Expression Data

Gene:	ins
Antibodies:	Ab1-gcg Ab2-isl
Fish:	WT med12^s435/s435
Anatomical Terms:	endocrine pancreas posterior pancreatic bud
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.