Gene
gata5
- ID
- ZDB-GENE-980526-340
- Name
- GATA binding protein 5
- Symbol
- gata5 Nomenclature History
- Previous Names
-
- gta5
- cb634 (1)
- fau
- faust
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of with a negative effect on gene expression. Acts upstream of or within several processes, including Kupffer's vesicle development; heart development; and post-embryonic foregut morphogenesis. Located in nucleus. Is expressed in several structures, including blastoderm; cardiovascular system; digestive system; mesoderm; and presumptive structure. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 68 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb634 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hsc115 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| hu3392 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ihb794 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb795 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| s26 | unknown | Unknown | Unknown | spontaneous | |
| sa17489 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24255 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43913 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tm236a | Allele with one point mutation | Intron 3 | Cryptic Splice Site | ENU | |
| wcm8 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Congenital heart defects, multiple types, 5 | 617912 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GATA-type transcription activator, N-terminal | Transcription factor GATA | Transcription factor GATA-4/5/6 | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9W6U0
|
383 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-73A2 | ZFIN Curated Data | |
| Encodes | EST | cb634 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:136430 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131235 (1) | 2204 nt | ||
| Genomic | GenBank:BX323800 (2) | 195592 nt | ||
| Polypeptide | UniProtKB:Q9W6U0 (1) | 383 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Li, X., Zeng, L., Qu, Z., Zhang, F. (2023) Huoxin pill protects verapamil-induced zebrafish heart failure through inhibition of oxidative stress-triggered inflammation and apoptosis. Heliyon. 10:e23402e23402
- Gurung, S., Restrepo, N.K., Chestnut, B., Klimkaite, L., Sumanas, S. (2022) Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Scientific Reports. 12:13065
- Kranert, K., Woźny, M., Podlasz, P., Wąsowicz, K., Brzuzan, P. (2022) MiR92b-3p synthetic analogue impairs zebrafish embryonic development, leading to ocular defects, decreased movement and hatching rate, and increased mortality. Journal of applied genetics. 64(1):145-157
- Prummel, K.D., Crowell, H.L., Nieuwenhuize, S., Brombacher, E.C., Daetwyler, S., Soneson, C., Kresoja-Rakic, J., Kocere, A., Ronner, M., Ernst, A., Labbaf, Z., Clouthier, D.E., Firulli, A.B., Sánchez-Iranzo, H., Naganathan, S.R., O'Rourke, R., Raz, E., Mercader, N., Burger, A., Felley-Bosco, E., Huisken, J., Robinson, M.D., Mosimann, C. (2022) Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nature communications. 13:1677
- Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
- Talbot, C.D., Walsh, M.D., Cutty, S.J., Elsayed, R., Vlachaki, E., Bruce, A.E.E., Wardle, F.C., Nelson, A.C. (2022) Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Frontiers in cell and developmental biology. 10:982477
- Winter, M.J., Ono, Y., Ball, J.S., Walentinsson, A., Michaelsson, E., Tochwin, A., Scholpp, S., Tyler, C.R., Rees, S., Hetheridge, M.J., Bohlooly-Y, M. (2022) A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation. Frontiers in pharmacology. 13:827686
- Fittipaldi, R., Floris, P., Proserpio, V., Cotelli, F., Beltrame, M., Caretti, G. (2021) The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 10(5):
- Ren, Q., Gao, D., Mou, L., Zhang, S., Zhang, M., Li, N., Sik, A., Jin, M., Liu, K. (2021) Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European Journal of Pharmacology. 912:174589
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