Gene
sox17
- ID
- ZDB-GENE-991213-1
- Name
- SRY-box transcription factor 17
- Symbol
- sox17 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in Kupffer's vesicle development; determination of left/right symmetry; and primitive hemopoiesis. Predicted to localize to nuclear transcription factor complex. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Is expressed in several structures, including Kupffer's vesicle; endoderm; lateral plate mesoderm; liver and biliary system; and presumptive structure. Orthologous to human SOX17 (SRY-box transcription factor 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 167 figures from 116 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91776 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| vesicoureteral reflux | Alliance | Vesicoureteral reflux 3 | 613674 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily |
|---|---|---|---|
|
UniProtKB:Q5PQZ5
|
413 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids