Figure 3
- ID
- ZDB-FIG-240813-19
- Publication
- Dasgupta et al., 2024 - Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
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Sema7A patterns the topology of the sensory arbor network. (A) A schematic drawing of the combined hair cell cluster (green) and associated sensory axons (magenta) shows diverse topological features of the arborization network, including nodes, loops, bare terminals, node degree, and bare-terminal curvature. The apex is defined as the center of the hair bundle cluster and the base is denoted by the node from which the arborizations extends. The relative organ height describes the position along the axis formed between the arborization initiation point and the apex of the hair cell cluster. (B) The correlation between the relative number of bare terminals and loops from 35 control neuromasts and 27 sema7a-/- neuromasts at 4 dpf shows a negative correlation in the control but a scattered distribution in the mutants. The same neuromasts were analyzed in the subsequent panels. R2, correlation coefficient. Dashed red line depicts the regression slope. (C) The relationship of contour lengths to bare terminals and loops reveals reduced looping in the mutants. (D) Quantification of the number of nodes per loop demonstrates a decrease in mutants. (E) Mutant larvae manifest a broader distribution of loop lengths compared to controls. (F) A schematic diagram of the extending bare terminals depicts regions of high and low curvature along the length of the arbor. The distributions of bare terminals between low- and high-curvature groups show an enrichment of long, highly curved arbors in the control and short, linear arbors in the mutants. Statistical analyses are displayed in Table 1. |