FIGURE

Figure 6.

ID

ZDB-FIG-240612-6

Publication

Rahmati et al., 2024 - Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay

Other Figures

(all 10)

All Figure Page

Back to All Figure Page

Figure 6.

NMD pathway in appb^−/−. A, Illustration of NMD pathway activation in appb^−/−. EJC, the exon-junction complex; PTC, premature termination codon. B, Relative appb mRNA expression levels in appb^−/− embryos injected with upf1MO (N = 12–15), upf2MO (N = 18–20), or upf3a/upf3bMO (N = 14–15) compared with uninjected appb^−/−. n = 3 biologically independent samples. Data shown as mean + SD. Student's two-tailed t test were used to calculate p values. *p < 0.05, **p < 0.01, ***p < 0.005, and ****p < 0.0001. ns, nonsignificant. Additional data relating to these analyses are provided in Extended Data Figure 6-1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ eNeuro