FIGURE

Figure 1.

ID

ZDB-FIG-240612-1

Publication

Rahmati et al., 2024 - Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay

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Figure 1.

appbMO-mediated loss of Mauthner cells in wild type but not appb^−/− zebrafish. A, Schematic image of the hindbrain region shown in B–F. B, C, Dorsal view of hindbrain of embryos (anterior to the top) stained with RMO44 antibody at 48 hpf, displaying the large Mauthner cells (MC) in wild type (B) and appb^−/− (C). D, E, Wild-type larvae injected with 1 ng splice-blocking appbMO showed two (22%), one (47%, D), or no MC (31%, E). F, two MC were observed in all appb^−/− injected with 1 ng splice-blocking appbMO. G, Quantification of the MC number at 48 hpf. G, n = 3 biologically independent samples. “N” indicates number of brains. r3–r5, rhombomeres 3–5. Scale bar, 50 μm. MC, Mauthner cells. Arrows indicate missing Mauthner cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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