FIGURE

Figure 2.

ID

ZDB-FIG-240612-2

Publication

Rahmati et al., 2024 - Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay

Other Figures

All Figure Page

Back to All Figure Page

Figure 2.

Relative gene expression in translation-blocking appbMO and appb^−/−. A, Relative expression level of appa, appb, aplp2, and aplp1 (N = 10) in morphants compared with wild type (WT; N = 10) at 24 hpf. B, Western blot analysis of Appb and GAPDH levels in wild type and translation-blocking appbMO at 3 dpf. C, Quantification of Western blot data. D, Relative expression of appa, appb, aplp1, and aplp2 at 24 hpf in genetic appb^−/− (N = 14) compared with WT (N = 14). E, Relative expression of appa, appb, aplp1, and aplp2 in adult brain of genetic appb^−/− mutants (N = 13) and wild-type siblings (N = 12). Wild-type expression levels were set at 1. Data shown as mean + SD. A–E, n = 3 biologically independent samples. Student's two-tailed t test was used to calculate p values. *p < 0.05, **p < 0.01, ***p < 0.005, and ****p < 0.001. Additional data relating to these analyses are provided in Extended Data Figure 2-1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ eNeuro