FIGURE

Fig. 1

ID

ZDB-FIG-210611-28

Publication

Griffin et al., 2021 - Phenotypic analysis of catastrophic childhood epilepsy genes

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Fig. 1

The Epilepsy Zebrafish Project (EZP).

a Overview of the zebrafish epilepsy disease model discovery workflow from human genome-wide association studies (GWAS) to the generation of zebrafish models and phenotypic characterization. b Heatmap of homology scoring for all EZP zebrafish lines generated. Red circles indicate genes for which mutant zebrafish lines were previously published. c Tissue expression profiles of EZP zebrafish target genes. Heatmap represents the maximum number of sequence reads for each gene per tissue. d Developmental gene expression profiles for EZP lines. e Representative frame-shift mutant lines confirmed for depdc5 and eef1a2.

Expression Data

Genes:	aldh7a1 arhgef9a arhgef9b arxa asah1b cdkl5 chd2 cntnap2a cntnap2b cpa6 depdc5 dnm1a dnm1b eef1a2 epm2a gabra1 gabrb3 gabrg2 gnao1a gnao1b gosr2 grin1a grin1b grin2aa hnrnpua hnrnpub kcna2b kcnma1a lgi1a mef2cb pafah1b1a pafah1b1b pcdh19 plcb1l pnpo prickle1a scn1ba scn1lab scn8aa scn8ab sik1 slc2a1a slc2a1b slc6a1a slc6a1b sptan1 st3gal3b strada stxbp1b syn1 syngap1a syngap1b tbc1d24
Fish:	TU WT
Anatomical Terms:	bone tissue brain gill heart intestine kidney muscle ovary testis whole organism
Stage Range:	4-cell to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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