Gene

syngap1a

ID

ZDB-GENE-060503-370

Name

synaptic Ras GTPase activating protein 1a

Symbol

syngap1a Nomenclature History

Previous Names

si:dkeyp-24a7.8

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be involved in regulation of GTPase activity and signal transduction. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 5. Is expressed in forebrain and hindbrain. Orthologous to human SYNGAP1 (synaptic Ras GTPase activating protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With syngap1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 5	Alliance	Intellectual developmental disorder, autosomal dominant 5	612621

Associated With syngap1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000008	C2 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Domain	IPR021887	Disabled homolog 2-interacting protein, C-terminal domain
Domain	IPR037779	SynGAP, PH domain
Family	IPR039360	Ras GTPase-activating protein
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	Disabled homolog 2-interacting protein, C-terminal domain	PH-like domain superfamily	Pleckstrin homology domain	Ras GTPase-activating domain	Ras GTPase-activating protein	Ras GTPase-activating protein, conserved site	Rho GTPase activation protein	SynGAP, PH domain
UniProtKB:A0A8M1RP05 InterPro	1311
UniProtKB:A0A8M2B5U5 InterPro	1313
UniProtKB:A0A8M2B5U2 InterPro	1295
UniProtKB:A0A8M3AJW4 InterPro	691
UniProtKB:A0A8M3AS94 InterPro	1210

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	syngap1a-201 (1) Ensembl	Ensembl		4,480 nt	Select Tool
mRNA	syngap1a-202 (1) Ensembl	Ensembl		3,768 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations