Gene
hnrnpub
- ID
- ZDB-GENE-030131-6422
- Name
- heterogeneous nuclear ribonucleoprotein Ub
- Symbol
- hnrnpub Nomenclature History
- Previous Names
-
- hnrnpu
- hnrpu (1)
- wu:fa66f11
- wu:fc18b08
- wu:fi89c08
- zgc:111835
- zgc:136480
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including basal RNA polymerase II transcription machinery binding activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including RNA localization to chromatin; regulation of cell cycle process; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Predicted to be part of CRD-mediated mRNA stability complex; catalytic step 2 spliceosome; and telomerase holoenzyme complex. Predicted to be active in several cellular components, including chromosome; microtubule cytoskeleton; and nuclear lumen. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 54. Orthologous to human HNRNPU (heterogeneous nuclear ribonucleoprotein U).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Griffin et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 54 | Alliance | Developmental and epileptic encephalopathy 54 | 617391 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001870 | B30.2/SPRY domain |
| Domain | IPR003034 | SAP domain |
| Domain | IPR003877 | SPRY domain |
| Domain | IPR035778 | Heterogeneous nuclear ribonucleoprotein U, SPRY domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036361 | SAP domain superfamily |
| Homologous_superfamily | IPR043136 | B30.2/SPRY domain superfamily |
Domain Details Per Protein
| Protein | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | Heterogeneous nuclear ribonucleoprotein U, SPRY domain | P-loop containing nucleoside triphosphate hydrolase | SAP domain | SAP domain superfamily | SPRY domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1ECZ7
|
795 | ||||||||
|
UniProtKB:Q5RHQ7
|
796 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hnrnpub-202
(1)
|
Ensembl | 4,350 nt | ||
| ncRNA |
hnrnpub-002
(1)
|
Ensembl | 406 nt |
Interactions and Pathways
No data available
Plasmids
No data available