Gene
gabra1
- ID
- ZDB-GENE-061013-194
- Name
- gamma-aminobutyric acid type A receptor subunit alpha1
- Symbol
- gabra1 Nomenclature History
- Previous Names
-
- zgc:153566 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Contributes to GABA-gated chloride ion channel activity. Involved in larval locomotory behavior. Acts upstream of or within protein heterotrimerization. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in nervous system. Used to study epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 19 and idiopathic generalized epilepsy 13. Orthologous to human GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022038Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s3014 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa43718 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| udm103 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 19 | Alliance | Developmental and epileptic encephalopathy 19 | 615744 |
| idiopathic generalized epilepsy 13 | Alliance | {Epilepsy, childhood absence, susceptibility to, 4} | 611136 |
| idiopathic generalized epilepsy 13 | Alliance | {Epilepsy, juvenile myoclonic, susceptibility to, 5} | 611136 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy with generalized tonic-clonic seizures | gabra1udm103/udm103 | standard conditions | Samarut et al., 2018 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Domain | IPR047024 | Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain |
| Domain | IPR047079 | Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain |
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Domain Details Per Protein
| Protein | Length | Gamma-aminobutyric-acid A receptor, alpha 1 subunit | Gamma-aminobutyric-acid A receptor, alpha subunit | Gamma-aminobutyric acid A receptor/Glycine receptor alpha | Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain | Gamma-aminobutyric acid receptor subunit alpha-1, extracellular domain | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ALU6
|
470 | ||||||||||||
|
UniProtKB:Q08BJ3
|
459 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabra1-201
(1)
|
Ensembl | 1,417 nt | ||
| mRNA |
gabra1-202
(1)
|
Ensembl | 1,077 nt | ||
| mRNA |
gabra1-203
(1)
|
Ensembl | 2,305 nt | ||
| mRNA | gabra1a-201 (1) | 1,417 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gabra1 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-145N14 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153566 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191715 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077326 (1) | 2332 nt | ||
| Genomic | GenBank:CR847531 (2) | 150363 nt | ||
| Polypeptide | UniProtKB:A0A8M3ALU6 (1) | 470 aa |
- Locubiche, S., Ordóñez, V., Abad, E., Scotto di Mase, M., Di Donato, V., De Santis, F. (2024) A Zebrafish-Based Platform for High-Throughput Epilepsy Modeling and Drug Screening in F0. International Journal of Molecular Sciences. 25(5):
- Nieoczym, D., Marszalek-Grabska, M., Szalak, R., Kundap, U., Kaczor, A.A., Wrobel, T.M., Kosheva, N., Komar, M., Abram, M., Esguerra, C.V., Samarut, E., Pieróg, M., Jakubiec, M., Kaminski, K., Kukula-Koch, W., Gawel, K. (2024) A comprehensive assessment of palmatine as anticonvulsant agent - In vivo and in silico studies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 172:116234116234
- Reyes-Nava, N.G., Paz, D., Pinales, B.E., Perez, I., Gil, C.B., Gonzales, A.V., Grajeda, B.I., Estevao, I.L., Ellis, C.C., Castro, V.L., Quintana, A.M. (2024) Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development. Differentiation; research in biological diversity. 138:100790100790
- Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
- Bampali, K., Koniuszewski, F., Vogel, F.D., Fabjan, J., Andronis, C., Lekka, E., Virvillis, V., Seidel, T., Delaunois, A., Royer, L., Rolf, M.G., Giuliano, C., Traebert, M., Roussignol, G., Fric-Bordat, M., Mazelin-Winum, L., Bryant, S.D., Langer, T., Ernst, M. (2023) GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell biology and toxicology. 39(6):2793-2819
- Ichikawa, S., Abe, R., Fujimoto, H., Higashi, K., Zang, L., Nakayama, H., Matsuoka, I., Shimada, Y. (2023) Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism. Frontiers in microbiology. 14:10791871079187
- Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
- Wang, Y., Liu, C., Deng, J., Xu, Q., Lin, J., Li, H., Hu, M., Hu, C., Li, Q., Xu, X. (2023) Behavioral and Sensory Deficits Associated with Dysfunction of GABAergic System in a Novel shank2-Deficient Zebrafish Model. International Journal of Molecular Sciences. 24(3):
- Barnaby, W., Dorman Barclay, H.E., Nagarkar, A., Perkins, M., Teicher, G., Trapani, J.G., Downes, G.B. (2022) GABAA α Subunit Control of Hyperactive Behavior in Developing Zebrafish. Genetics. 220(4):
- Myren-Svelstad, S., Jamali, A., Ophus, S.S., D'gama, P.P., Ostenrath, A.M., Mutlu, A.K., Hoffshagen, H.H., Hotz, A.L., Neuhauss, S.C.F., Jurisch-Yaksi, N., Yaksi, E. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia. 63:2543-2560
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