FIGURE

Fig. S9

ID

ZDB-FIG-140506-62

Publication

Pavlou et al., 2014 - Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus

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Fig. S9

Simultaneous knockdown of sox2 and BMP rescues the number of PhRs. (A) DMSO-treated control embryos at 28 hpf, with PhR in green (Tg(aanat2:GFP)) and Sox2 in red. (B) Dorsomorphin treatment, that inhibits the BMP pathway, leads to a reduced number of PhRs, while Sox2 expression is normal. (C) Knockdown of sox2 leads to increased number of PhRs. (D) Simultaneous inhibition of sox2 and BMP results in a number of PhR similar to the DMSO-treated control siblings. (E) Average number of PhR in DMSO-treated (purple bar), dorsomorphin-treated (green bar), sox2 morphant treated with DMSO (orange bar) and sox2 morphant treated with dorsomorphin (red bar) embryos. Confocal maximum projections of 28 hpf embryos, error bars represent ± standard error, * = p-value <0.05 (MWU test), ** = p-value <0.001 (MWU test).

Expression Data

Gene:	EGFP
Antibody:	Ab3-sox2
Fish:	y8Tg y8Tg + MO6-sox2
Conditions:	chemical treatment: pharmaceutical chemical treatment: dorsomorphin
Knockdown Reagent:	MO6-sox2
Anatomical Terms:	epithalamus pineal complex photoreceptor cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y8Tg y8Tg + MO6-sox2
Conditions:	chemical treatment: pharmaceutical chemical treatment: dorsomorphin
Knockdown Reagent:	MO6-sox2
Observed In:	pineal complex photoreceptor cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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