FIGURE

Fig. S8

ID

ZDB-FIG-140506-61

Publication

Pavlou et al., 2014 - Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus

Other Figures

All Figure Page

Back to All Figure Page

Fig. S8

Downregulation of BMP does not affect sox2 expression at 15 ss. (A-E′′) sox2 is expressed throughout the pineal anlage and is downregulated in isl1-positive cells, in DMSO-treated control embryos. (A-E) sox2 expression, (A′-E′) isl1 expression, (A′′-E′′) merged images of sox2, isl1 and Tg(flh:GFP), showing the presumptive pineal gland. (F-J′′) Dorsomorphin treatment (40 µM) does not affect sox2 expression at 15 ss. sox2 is expressed in the pineal precursors and is downregulated with differentiation (as shown by isl1-positive cells). (F-J) sox2 expression, (F′-J′) isl1 expression, (F′′-J′′) merged images of sox2, isl1 and Tg(flh:GFP). Series of optical sections from dorsal (first column) to ventral (5^th column) obtained using confocal microscope, scale bars = 25 µm, yellow arrows show cells in which sox2 is downregulated and isl1 is upregulated, insets show a three times magnified view of the image. See also Figure 6, Movie S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One