FIGURE

Fig. 6

ID

ZDB-FIG-140506-51

Publication

Pavlou et al., 2014 - Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus

Other Figures

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Fig. 6

Sox2 controls PhR cell fate independently of BMP.

(A) The transgenic line Tg(aanat2:GFP) marks the PhRs. (B) The transgenic line Tg(BRE:GFP) is as a BMP signaling reporter. (C) In sox2 morphant embryos, the number of PhRs is increased at 24 hpf, when compared to controls (A). (D) The number of BMP-responsive cells at 24 hpf is unaffected when sox2 is knocked down. (E–F) The number of PhRs (E) and BMP-responsive cells (F) is similar in control embryos at 28 hpf. (G–H) The number of PhRs (G) is higher than the number of BMP-responsive cells (H) at 28 hpf, in sox2 morphants. (I) The average number of PhRs (Tg(aanat2:GFP)-positive cells) and BMP-responsive cells (Tg(BRE:GFP)-positive cells) in control and sox2 morphant embryos, at 24 and 28 hpf. Confocal maximum projections, scale bars = 25 μm, error bars represent ± standard error, ** = p-value <0.001 (MWU test). See also Figure S8 and Movie S3.

Expression Data

Gene:	EGFP
Fish:	mw30Tg y8Tg mw30Tg + MO6-sox2 y8Tg + MO6-sox2
Knockdown Reagent:	MO6-sox2
Anatomical Term:	pineal complex photoreceptor cell
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y8Tg + MO6-sox2
Knockdown Reagent:	MO6-sox2
Observed In:	pineal complex photoreceptor cell
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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