FIGURE

Fig. 7

ID

ZDB-FIG-140506-52

Publication

Pavlou et al., 2014 - Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus

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Fig. 7

Knockdown of sox2 results in abnormal parapineal development and disruption of the habenular asymmetries.

(A) gfi1ab is expressed in parapineal cells on the left side of the brain in control embryos. (B–D) sox2 morphants are categorized into three groups according to gfi1ab expression: left-sided expression (B), right-sided (C) and embryos with scattered gfi1ab cells (D). (E) kctd12.1 is asymmetrically expressed in the habenulae, with a broader expression domain in the left than the right habenula. (F–H) In sox2 morphants kctd12.1 expression can be: asymmetric with more on the left side similar to control embryos (F), asymmetric with more on the right side (G) or symmetric (H). (I) A table showing the percentage of embryos with normal, reversed or bilateral parapineal organs, using different staining methods. Scale bars = 25 μm. See also Figure S9–S10 and Movie S4.

Expression Data

Genes:	gfi1ab kctd12.1
Fish:	WT WT + MO6-sox2
Knockdown Reagent:	MO6-sox2
Anatomical Terms:	habenula parapineal organ
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO6-sox2
Knockdown Reagent:	MO6-sox2
Observed In:	determination of left/right asymmetry in diencephalon habenula development parapineal organ determination of left/right asymmetry in diencephalon parapineal organ epithalamus development
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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