ZFIN Image: Shin et al., 2008, Fig. 2

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Figure Caption

Fig. 2 shr is required for dorsal pancreas development. Confocal projections of wild-type and shr^s435 mutant embryos at 34 (A–D′) and 56 (E–H′) hpf stained for Islet (red, A, A′, E, E′), Insulin (green, B, B′, F, F′), Glucagon (red, C, C′, G, G′), and Somatostatin (green, D, D′, H, H′) expression. The pancreatic expression of Islet and Insulin appears unaffected in shr^s435 mutants at 34 and 56 hpf (A′, B′, E′, F′). The expression of Somatostatin appears reduced (D′) and that of Glucagon almost completely absent (C′) in shr^s435 mutants at 34 hpf, but restored to wild-type levels by 56 hpf (G′, H′). All images are ventral views, anterior to the top.

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Acknowledgments

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Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.