Publication	Data		Fish	Anatomy
Chen et al., 2021	FIGURE 4		WT + MO3-pkd2	pronephros cystic, abnormal
Derrick et al., 2021	Figure 6		pkd2hu2173/hu2173	heart tube hapln1a expression spatial pattern, abnormal heart tube random pattern, abnormal
Oliveira et al., 2021	Figure 1		AB + MO9-pkd2	Kupffer's vesicle ciliary basal body ab2-pkd2 labeling decreased distribution, abnormal Kupffer's vesicle ciliary membrane ab2-pkd2 labeling decreased distribution, abnormal
	Figure 3		pd1041Tg + MO9-pkd2 (AB)	Kupffer's vesicle apical plasma membrane GFP expression increased amount, abnormal Kupffer's vesicle apical plasma membrane GFP expression increased distribution, abnormal Kupffer's vesicle GFP expression increased amount, abnormal Kupffer's vesicle GFP expression increased distribution, abnormal
	Figure 4		pd1041Tg + MO9-pkd2 (AB)	Kupffer's vesicle GFP expression increased amount, abnormal
	Figure 5		AB + MO9-pkd2 ,   s870Tg + MO9-pkd2 (AB)	heart tube embryonic heart tube left/right pattern formation process quality, abnormal Kupffer's vesicle increased volume, abnormal post-vent region curved, abnormal
Metzner et al., 2020	Figure 1		pkd2hu2173/hu2173	caudal fin curved, abnormal
	Figure 2		pkd2hu2173/hu2173	caudal fin curved, abnormal
	Figure 3		pkd2hu2173/hu2173 ,   pkd2hu2173/hu2173; li1Tg	caudal fin curved, abnormal posteromedial glomerulus dilated, abnormal
Verschuren et al., 2020	Fig. 7		TL + MO3-pkd2	pericardium edematous, abnormal post-vent region curved, abnormal pronephros cystic, abnormal whole organism decreased life span, abnormal
Arhatte et al., 2019	Fig. 8		li1Tg + MO3-pkd2	pronephric glomerulus cystic, abnormal pronephric glomerulus increased diameter, abnormal
Duchemin et al., 2019	Figure 8		pkd2tc321/tc321; ig11Tg ,   pkd2tc321/tc321; y173Tg; zf495Tg	bulbus arteriosus endocardial cushion EGFP expression decreased amount, abnormal ventriculo bulbo valve development decreased process quality, abnormal ventriculo bulbo valve morphogenesis decreased process quality, abnormal
Liu et al., 2019	Fig. 6		WT + MO3-pkd2	whole organism dcn expression decreased amount, abnormal
Liu et al., 2019	Fig. 2		hsc5Tg; pku6Tg + MO3-pkd2	blood vessel cilium decreased amount, abnormal blood vessel cilium decreased length, abnormal
	Fig. 3		AB + MO3-pkd2 ,   pkd2ouc2015/ouc2015 + MO3-pkd2	hematopoietic progenitor cell differentiation decreased occurrence, abnormal ventral wall of dorsal aorta myb expression decreased amount, abnormal ventral wall of dorsal aorta myb expression decreased distribution, abnormal ventral wall of dorsal aorta runx1 expression decreased amount, abnormal ventral wall of dorsal aorta runx1 expression decreased distribution, abnormal
	Fig. 5		AB + MO3-pkd2	hematopoietic progenitor cell differentiation decreased occurrence, abnormal ventral wall of dorsal aorta runx1 expression decreased amount, abnormal ventral wall of dorsal aorta runx1 expression decreased distribution, abnormal ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount, abnormal
	Fig. 6		jh11Tg; y1Tg + MO3-pkd2	ventral wall of dorsal aorta endothelial cell mCherry expression decreased amount, abnormal
Pala et al., 2019	Fig. S13		AB + MO3-pkd2	blood vessel decreased diameter, abnormal heart decreased functionality, abnormal kidney cystic, abnormal post-vent region curved, abnormal
	Fig. S14		AB + MO3-pkd2	artery cilium decreased length, abnormal heart cilium decreased length, abnormal
Sun et al., 2019	Fig. 4		WT + MO3-pkd2	head hydrocephalic, abnormal pronephros cystic, abnormal whole organism curved dorsal, abnormal
Ferreira et al., 2018	Fig. S4		pkd2tc321/tc321	determination of digestive tract left/right asymmetry decreased occurrence, abnormal determination of digestive tract left/right asymmetry occurrence, abnormal determination of heart left/right asymmetry decreased occurrence, abnormal determination of heart left/right asymmetry occurrence, abnormal determination of left/right asymmetry in lateral mesoderm decreased occurrence, abnormal determination of left/right asymmetry in lateral mesoderm occurrence, abnormal
Hofherr et al., 2018	Fig. 7		pkd2tc321/tc321	heart looping disrupted, abnormal
	Fig. S8		hsc5Tg + MO6-pkd2	determination of left/right symmetry disrupted, abnormal head lft2 expression spatial pattern, abnormal Kupffer's vesicle dand5 expression spatial pattern, abnormal mesoderm spaw expression mislocalised, abnormal
Xu et al., 2018	Fig. 1		TU + MO3-pkd2	pronephric duct Ab2-scrib labeling decreased amount, abnormal whole organism Ab2-scrib labeling decreased amount, abnormal
	Fig. 2		TU + MO3-pkd2	pronephric duct cystic, abnormal
	Fig. 5		TU + MO3-pkd2	pronephric duct cystic, abnormal whole organism ccn1 expression increased amount, abnormal whole organism ccn2a expression increased amount, abnormal whole organism Ab2-lats1 labeling decreased amount, abnormal whole organism Ab3-lats1 labeling decreased amount, abnormal whole organism Ab3-yap1 labeling decreased amount, abnormal
	Fig. 7		TU + MO3-pkd2	pronephric duct cystic, abnormal
Zheng et al., 2018	Fig. 4		AB + MO3-pkd2	post-vent region curled, abnormal pronephric tubule dilated, abnormal pronephros cystic, abnormal
Chang et al., 2017	Fig. 1		li1Tg + MO3-pkd2	pronephros cystic, abnormal pronephros morphogenesis decreased process quality, abnormal
	Fig. 2		li1Tg + MO3-pkd2	post-vent region curved dorsal, abnormal vent malformed, abnormal
	Fig. 3		WT + MO3-pkd2	pronephric duct epithelial cell proliferation increased occurrence, abnormal pronephros morphogenesis decreased process quality, abnormal
	Fig. 4		WT + MO3-pkd2	pronephric duct anatomical region has extra parts of type leukocyte, abnormal pronephros morphogenesis decreased process quality, abnormal
	Fig. 7		li1Tg + MO3-pkd2	pronephric duct Ab6-map1lc3b labeling decreased amount, abnormal pronephric duct Ab6-map1lc3b labeling decreased distribution, abnormal pronephric duct autophagy decreased occurrence, abnormal pronephros cystic, abnormal pronephros morphogenesis decreased process quality, abnormal
Arif Pavel et al., 2016	Fig. 6		WT + MO3-pkd2 ,   li1Tg + MO3-pkd2	post-vent region curved dorsal, abnormal post-vent region increased curvature, abnormal pronephric glomerulus cystic, abnormal pronephric glomerulus dilated, abnormal pronephric glomerulus EGFP expression increased distribution, abnormal
Steed et al., 2016	Fig. 6		pkd2tc321/tc321; ubs10Tg	atrioventricular canal ab2-fn labeling decreased amount, abnormal
Zheng et al., 2016	Fig. 6		AB + MO3-pkd2	post-vent region curved, abnormal
	Fig. 7		AB + MO3-pkd2	pronephric tubule dilated, abnormal pronephros cystic, abnormal
Heckel et al., 2015	Fig. 3		pkd2tc321/tc321; ubs10Tg ,   pkd2tc321/tc321 ,   pkd2tc321/tc321; ig11Tg	atrioventricular canal endocardium EGFP expression decreased amount, abnormal atrioventricular canal morphogenesis decreased occurrence, abnormal atrioventricular valve morphology, abnormal atrioventricular valve shape, abnormal
	Fig. 4		pkd2tc321/tc321; ubs3Tg; zf350Tg	atrioventricular canal GCaMP expression decreased amount, abnormal
	Fig. S3		ig11Tg + MO4-pkd2 ,   pkd2tc321/tc321; ubs10Tg	atrioventricular canal EGFP expression decreased amount, abnormal atrioventricular canal endocardium endothelial cell decreased amount, abnormal
Roxo-Rosa et al., 2015	Fig. 1		WT + MO3-pkd2 + MO9-pkd2	determination of heart left/right asymmetry decreased process quality, abnormal heart mislocalised, abnormal Kupffer's vesicle cytoplasm pkd2 expression decreased amount, abnormal Kupffer's vesicle motile cilium pkd2 expression absent, abnormal post-vent region curved dorsal, abnormal
	Fig. 4		WT + MO3-pkd2 + MO9-pkd2	Kupffer's vesicle development process quality, abnormal Kupffer's vesicle increased area, abnormal
Yuan et al., 2015	Fig. 2		WT + MO3-pkd2	Kupffer's vesicle calcium-mediated signaling process quality, abnormal
	Fig. 4		WT + MO3-pkd2	hypoblast calcium-mediated signaling process quality, abnormal
Aboualaiwi et al., 2014	Fig. 8		AB + MO3-pkd2	post-vent region curved, abnormal pronephros cystic, abnormal whole organism chromosome increased amount, abnormal
Coxam et al., 2014	Fig. 2		hu5333Tg; y1Tg + MO4-pkd2 ,   WT + MO4-pkd2	thoracic duct absent, abnormal thoracic duct malformed, abnormal whole organism curved dorsal, abnormal
	Fig. S3		WT + MO4-pkd2	thoracic duct malformed, abnormal
Le Corre et al., 2014	Fig. 1		AB/TU + MO7-pkd2	whole organism anterior-posterior axis curved dorsal, abnormal
	Fig. 2		li1Tg + MO7-pkd2 ,   AB/TU + MO7-pkd2	pronephros cystic, abnormal whole organism anterior-posterior axis curved dorsal, abnormal
	Fig. 4		pkd2tc321/tc321 ,   AB/TU + MO7-pkd2	whole organism anterior-posterior axis curved dorsal, abnormal
	Fig. 5		li1Tg + MO7-pkd2	pronephros cystic, abnormal
Sussman et al., 2014	Fig. 6		WT + MO3-pkd2	brain hydrocephalic, abnormal pronephros cystic, abnormal trunk increased curvature, abnormal
Paavola et al., 2013	Fig. 1		pkd2hi4166Tg/hi4166Tg	heart edematous, abnormal post-vent region curved dorsal, abnormal
	Fig. 2		pkd2hi4166Tg/hi4166Tg	heart contraction arrhythmic, abnormal heart contraction decreased rate, abnormal heart edematous, abnormal
	Fig. 3		pkd2hi4166Tg/hi4166Tg	heart contraction arrhythmic, abnormal heart contraction asynchronous, abnormal
	Fig. 4		pkd2hi4166Tg/hi4166Tg	regulation of cardiac muscle contraction by calcium ion signaling decreased process quality, abnormal
	Fig. 5		pkd2hi4166Tg/hi4166Tg	regulation of cardiac muscle contraction by calcium ion signaling decreased process quality, abnormal
	Fig. 6		pkd2hi4166Tg/hi4166Tg	regulation of cardiac muscle contraction by calcium ion signaling decreased process quality, abnormal
	Fig. S5		pkd2hi4166Tg/hi4166Tg	ventricular cardiac muscle cell action potential decreased process quality, abnormal
Chang et al., 2011	Fig. 2		li1Tg + MO3-pkd2	pronephric duct cystic, abnormal pronephric glomerulus dilated, abnormal pronephric tubule dilated, abnormal
	Fig. 4		WT + MO3-pkd2	cell proliferation involved in pronephros development increased occurrence, abnormal
	Fig. S1		WT + MO3-pkd2	gut edematous, abnormal
Fogelgren et al., 2011	Fig. 4		WT + MO3-pkd2	post-vent region curved, abnormal
	text only		WT + MO3-pkd2	determination of left/right symmetry process quality, abnormal
Rothschild et al., 2011	Fig. 8		WT + MO3-pkd2 ,   zf34Tg + MO3-pkd2	calcium/calmodulin-dependent protein kinase activity decreased occurrence, abnormal
	Fig. 9		WT + MO3-pkd2	brain hydrocephalic, abnormal cloacal chamber cilium decreased amount, abnormal cloacal chamber cilium decreased length, abnormal inner ear posterior-most region increased distance pronephric duct anterior-most region, abnormal post-vent region curved dorsal, abnormal pronephric duct distal region obstructed, abnormal pronephros anterior region structure, abnormal pronephros anterior region truncated, abnormal
Bouvrette et al., 2010	Fig. 3		WT + MO3-pkd2	trunk curved dorsal, abnormal
Francescatto et al., 2010	Fig. 7		WT + MO3-pkd2	calcium/calmodulin-dependent protein kinase activity decreased rate, abnormal protein autophosphorylation decreased occurrence, abnormal
Giamarchi et al., 2010	Fig. 8		WT + MO3-pkd2	brain hydrocephalic, abnormal determination of heart left/right asymmetry disrupted, abnormal heart edematous, abnormal heart looping disrupted, abnormal heart mislocalised, abnormal pronephros cystic, abnormal whole organism increased curvature, abnormal
Hurd et al., 2010	Fig. 7		twu34Tg + MO3-pkd2	heart looping process quality, abnormal
Mangos et al., 2010	Fig. 2		WT + MO7-pkd2	brain hydrocephalic, abnormal post-vent region curved dorsal, abnormal
	Fig. 3		WT + MO7-pkd2	post-vent region curved dorsal, abnormal
	Fig. 4		pkd2hi4166Tg/hi4166Tg	notochord physical object quality, abnormal regulation of collagen biosynthetic process process quality, abnormal
	Fig. 5		WT + MO7-pkd2	post-vent region curved dorsal, abnormal
Cao et al., 2009	Fig. 1		pkd2hi4166Tg/hi4166Tg (AB/TU) ,   AB/TU + MO3-pkd2	pronephros cystic, abnormal whole organism curved dorsal, abnormal
	Fig. 4		pkd2hi4166Tg/hi4166Tg (AB/TU)	whole organism curved dorsal, abnormal
	Fig. S1		pkd2hi4166Tg/hi4166Tg (AB/TU)	whole organism curved dorsal, abnormal
Vasilyev et al., 2009	Fig. 7		sqet33D10Et + MO7-pkd2 (AB)	cell migration arrested, abnormal proximal convoluted tubule development arrested, abnormal
Yuan et al., 2009	Fig. 1		WT + MO3-pkd2	post-vent region curved dorsal, abnormal
Feng et al., 2008	Fig. 4		AB + MO3-pkd2	brain hydrocephalic, abnormal pronephros cystic, abnormal whole organism increased curvature, abnormal
Fu et al., 2008	Fig. 4		WT + MO6-pkd2	brain hydrocephalic, abnormal pronephric glomerulus decreased thickness, abnormal pronephric tubule dilated, abnormal pronephros cystic, abnormal whole organism curved dorsal, abnormal
	Fig. 5		WT + MO6-pkd2	brain hydrocephalic, abnormal pronephros cystic, abnormal whole organism curved dorsal, abnormal
	Fig. 6		WT + MO6-pkd2	determination of left/right symmetry disrupted, abnormal digestive system morphology, abnormal heart looping disrupted, abnormal heart morphology, abnormal
Köttgen et al., 2008	Fig. 4		WT + MO5-pkd2	brain hydrocephalic, abnormal post-vent region curved dorsal, abnormal pronephric glomerulus morphology, abnormal pronephric tubule dilated, abnormal pronephros cystic, abnormal
Sullivan-Brown et al., 2008	Fig. 8		WT + MO3-pkd2	pronephric glomerulus increased size, abnormal
Schottenfeld et al., 2007	Fig. 1		pkd2tc321/tc321 ,   pkd2ty30/ty30	post-vent region curved, abnormal
	Fig. 2		pkd2tc321/tc321 ,   pkd2ty30/ty30	determination of left/right symmetry process quality, abnormal
	Fig. 3		pkd2tc321/tc321 ,   pkd2ty30/ty30	determination of left/right symmetry process quality, abnormal
	Fig. 5		WT + MO10-pkd2 ,   pkd2tc321/tc321 ,   WT + MO9-pkd2	brain hydrocephalic, abnormal determination of left/right symmetry process quality, abnormal post-vent region curved, abnormal pronephric duct cystic, abnormal renal glomerulus cystic, abnormal
	Fig. Table 1		WT + MO10-pkd2 ,   pkd2tc321/tc321 ,   WT + MO9-pkd2 ,   pkd2ty30/ty30	determination of left/right symmetry process quality, abnormal
	text only		WT + MO10-pkd2 ,   pkd2tc321/tc321 ,   pkd2ty30/ty30	post-vent region curved, abnormal whole organism edematous, abnormal
Obara et al., 2006	Fig. 5		WT + MO5-pkd2 ,   WT + MO7-pkd2 ,   WT + MO8-pkd2	head hydrocephalic, abnormal pronephric duct increased size, abnormal pronephros cystic, abnormal whole organism anterior-posterior axis curved dorsal, abnormal
	Fig. 6		WT + MO5-pkd2	determination of left/right symmetry disrupted, abnormal
	Fig. 7		WT + MO5-pkd2	pronephric duct increased size, abnormal pronephros cystic, abnormal whole organism anterior-posterior axis curved dorsal, abnormal
	Fig. 9		WT + MO5-pkd2	pronephric duct opening decreased size, abnormal
Phenotype Annotation (1994-2006)	Fig. for (hi4166)		pkd2hi4166Tg	post-vent region curved, abnormal pronephros quality, abnormal
	Fig. for (tc321)		pkd2tc321/tc321	post-vent region curved, abnormal whole organism lethal (sensu genetics), abnormal whole organism shape, abnormal
	Fig. for (tg226d)		pkd2tg226d/tg226d	post-vent region curved, abnormal whole organism lethal (sensu genetics), abnormal whole organism shape, abnormal
	Fig. for (tp85a)		pkd2tp85a/tp85a	post-vent region curved, abnormal whole organism lethal (sensu genetics), abnormal whole organism shape, abnormal
	Fig. for (ty30)		pkd2ty30/ty30	post-vent region curved, abnormal whole organism lethal (sensu genetics), abnormal whole organism shape, abnormal
Amsterdam et al., 2004	text only		pkd2hi4166Tg/hi4166Tg	trunk curved dorsal, abnormal
Sun et al., 2004	Fig. 1		WT + MO3-pkd2	post-vent region increased curvature, abnormal pronephros cystic, abnormal
	Table 2		WT + MO3-pkd2	post-vent region increased curvature, abnormal pronephros cystic, abnormal
Brand et al., 1996	Fig. 1		pkd2tc321/tc321 ,   pkd2tg226d/tg226d ,   pkd2ty30/ty30 ,   pkd2tp85a/tp85a	post-vent region curved dorsal, abnormal whole organism shape, abnormal whole organism viability, abnormal