FIGURE

FIGURE 4

ID

ZDB-FIG-211025-71

Publication

Chen et al., 2021 - NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models

Other Figures

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FIGURE 4

NS398 reduces cyst formation in vivo. (A) Representative images of Pkd2 morphants treated with vehicle (DMSO) or NS398. (B) Quantification showing the average percentage of embryos with kidney cysts in the two groups from three independent experiments. Fifty embryos per group were examined in each experiment. (C) and (D) Representative immunohistochemical images of kidneys and scans of whole kidneys isolated from Pkd1‐knockout mice treated with the vehicle (DMSO) or 20 μg/g NS398, stained with HE. (E), (F), and (G) Quantitative analysis of kidney/body weight ratio, CI, and BUN levels of wild‐type, diseased and NS398‐treated mice (n = 5 per group; p < 0.05.) (H) Western blot showing the effects of NS398 on the levels of phospho‐ and total Akt and ERK in diseased and NS398‐treated mice (*p < 0.05, t test)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-pkd2
Condition:	chemical treatment by environment: NS-398
Knockdown Reagent:	MO3-pkd2
Observed In:	pronephros
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell. Mol. Med.