Fig. 8
- ID
- ZDB-FIG-080324-16
- Publication
- Sullivan-Brown et al., 2008 - Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants
- Other Figures
- All Figure Page
- Back to All Figure Page
pkd2 morphants develop glomerular dilations, but do not become dilated in the tubular region of the nephron. (A–D) Glomerular region comparison at 3 dpf of a wild-type sibling embryo (A), pkd2 morphants (B, C) and a locke mutant embryo (D). Black arrows mark the glomerulus, which is clearly dilated in both pkd2 morphants and locke mutant embryos. (E–H) Anterior tubule region, immediately posterior to the glomerulus; although the tubules exhibit dilation in locke mutant embryos (H), the tubules in pkd2 morphants (F, G) are not enlarged and resemble wild-type sibling tubules (E). (I–L) Medial tubule region; unlike locke mutant embryos (L), the lumens of the medial tubules are not dilated in pkd2 morphants (J, K), similar to wild-type siblings (I). Black arrowheads indicate tubules. All pictures are from JB-4 plastic sections, stained with an H&E dye, and taken with 40x lens (A–H) and 100x oil lens (I–L). |
| Fish: | |
|---|---|
| Knockdown Reagent: | |
| Observed In: | |
| Stage: | Protruding-mouth |
Reprinted from Developmental Biology, 314(2), Sullivan-Brown, J., Schottenfeld, J., Okabe, N., Hostetter, C.L., Serluca, F.C., Thiberge, S.Y., and Burdine, R.D., Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants, 261-275, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.