FIGURE

Fig. 1

ID

ZDB-FIG-070421-15

Publication

Schottenfeld et al., 2007 - Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw

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Fig. 1

Identification and structural analysis of cup/pkd2. (A) Mapping of the cup mutation to a genetic interval on chromosome 1. The number of recombinants at each marker is shown. (B) pkd2 encodes a six-pass transmembrane calcium-activated non-specific cation channel [structure modified from Hayashi et al. (Hayashi et al., 1997)]. Sequencing of pkd2 in tc321 mutants revealed a nonsense mutation at nucleotide position 407 and ty30b showed a missense mutation at nucleotide position 1052, resulting in an amino acid substitution from a leucine to proline. (C) Lateral image of wild-type, cup^tc321, and cup^ty30b embryos at 48 hpf. Both alleles have a curly tail upward phenotype, but ty30b has a milder curvature than that of tc321.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pkd2^tc321/tc321 pkd2^ty30/ty30
Observed In:	post-vent region
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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