FIGURE

Figure 5

ID

ZDB-FIG-230821-5

Publication

Yang et al., 2023 - Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae

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Figure 5

Relative expression of hypothalamic–pituitary–thyroid (HPT) axis related genes in zebrafish embryos following exposure to different concentrations (0, 10, 50, 100 nM) of pazopanib and axitinib for 96 h. (A, B) for pazopanib and axitinib, respectively. Data are expressed as the mean ± SD, n = 6 (60 embryos per concentration, with three replicates). Different letters indicate a statistically significant difference between groups, P < 0.05, One-way ANOVA test followed by Tukey’s multiple comparison.

Expression Data

Genes:	dio1 dio2 pax8 slc5a5 tg thraa thrb tpo trh tshba tshr ttr
Fish:	WT
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Observed In:	whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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