FIGURE

Figure 3

ID

ZDB-FIG-230821-3

Publication

Yang et al., 2023 - Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae

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Figure 3

Whole-mount in situ hybridization (WISH) of tg and tshβ in zebrafish embryos following exposure to 100 nM of pazopanib and axitinib for 96 h (A) WISH of tg. (B) The relative reduction in thyroid area (%). (C) WISH of tshβ. (D) Relative reduction in thyroid area (%). Data are expressed as the mean ± SD, n = 3 (20 embryos per concentration, with three replicates). Different letters indicate a statistically significant difference between groups, P < 0.05, One-way ANOVA test followed by Tukey’s multiple comparison.

Expression Data

Genes:	tg tshba
Fish:	WT
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Anatomical Term:	thyroid follicle
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Observed In:	thyroid follicle
Stage:	Day 4

Phenotype Detail

Acknowledgments

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