FIGURE

Figure 1

ID

ZDB-FIG-230821-1

Publication

Yang et al., 2023 - Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae

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Figure 1

Developmental toxicities and survival of zebrafish embryos following exposure to different concentrations (0, 10, 50, 100 nM) of pazopanib and axitinib for 96 (h) (A, B) Dead embryos, (C, D) hatchability and larval survival rates, (E, F) time to hatching (days), and (G, H) body length (mm). Relative thyroid follicle numbers were analyzed from D-F. Data are expressed as the mean ± SD, n = 3 (48 embryos per concentration, with three replicates). Different letters indicate a statistically significant difference between groups, P < 0.05, One-way ANOVA test followed by Tukey’s multiple comparison.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Observed In:	hatching whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)