Gene

ttr

ID

ZDB-GENE-040927-14

Name

transthyretin (prealbumin, amyloidosis type I)

Symbol

ttr Nomenclature History

Previous Names

zgc:103583

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have hormone activity and thyroid hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Is expressed in liver. Orthologous to human TTR (transthyretin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103583 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ttr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
carpal tunnel syndrome 1	Alliance	Carpal tunnel syndrome, familial	115430
dystransthyretinemic hyperthyroxinemia	Alliance	[Dystransthyretinemic hyperthyroxinemia]	145680
transthyretin amyloidosis	Alliance	Amyloidosis, hereditary, transthyretin-related	105210

Associated With ttr Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023416	Transthyretin/hydroxyisourate hydrolase domain
Family	IPR000895	Transthyretin/hydroxyisourate hydrolase
Homologous_superfamily	IPR036817	Transthyretin/hydroxyisourate hydrolase domain superfamily