FIGURE

Figure 4

ID

ZDB-FIG-230821-4

Publication

Yang et al., 2023 - Influence of two anti-tumor drugs, pazopanib, and axitinib, on the development and thyroid-axis of zebrafish (Danio rerio) embryos/larvae

Other Figures

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Figure 4

Morphology and histopathology of the thyroid in zebrafish embryos following exposure to 100 nM of pazopanib and axitinib for 96 h (A) Confocal imaging analyses of the thyroid in transgenic Tg (tg: EGFP) embryos. (B) The relative reduction in thyroid volume (%) from (A, D-F) H&E staining of zebrafish embryos. (C) The size of the follicles was analyzed from D-F. (G) Relative thyroid follicle numbers were analyzed from D-F. Data are expressed as the mean ± SD, n = 6. Different letters indicate a statistically significant difference between groups, P < 0.05, One-way ANOVA test followed by Tukey’s multiple comparison.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ioz4Tg
Conditions:	chemical treatment by environment: axitinib chemical treatment by environment: pazopanib
Observed In:	thyroid follicle
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)