FIGURE

Fig. 12

ID
ZDB-FIG-190812-15
Publication
Elworthy et al., 2019 - The role of endothelial cilia in post-embryonic vascular development
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Fig. 12

Endothelial‐specific excision of the Tg(ubi:loxP‐ift54‐loxP‐myr‐mcherry,myl7:EGFP)sh488‐rescuing transgene causes no apparent further impairment to perivascular mural cells in the caudal fin vascular plexus of ift54 tp49Tg(ubi:loxP‐ift54‐loxP‐myr‐mcherry,myl7:EGFP)sh488 fish. A: Confocal stack projections showing mcherry fluorescence from 17‐dpf caudal fins of ift54tp4; Tg(ubi:loxP‐ift54‐loxP‐myr‐mcherry,myl7:EGFP)sh488 /+; Tg(tagln:mcherry)sh441 /+ (ift54−/−; ubi:ift54; tagln:mcherry) and ift54 tp4; Tg(ubi:loxP‐ift54‐loxP‐myr‐mcherry,myl7:EGFP)sh488/+;Tg(kdrl:cre)s898; Tg(tagln:mcherry)sh441 /+ (ift54−/−; ubi:ift54; tagln:mcherry; kdrl:cre). Also shown are binary threshold processed images as used for quantification of the area of Tg(tagln:mcherry)sh441 /+ expression. Single‐focal‐plane transmitted light views are shown for orientation. B: Chart shows % of field of view with >threshold mcherry expression as measured from processed confocal projections of caudal fins. Overlay shows median and interquartile range. Two‐tailed Mann‐Whitney test P = 0.5362. The Tg(kdrl:cre)s898 /+ caused no apparent impairment to mural cell coverage in the newly developed fin vascular bed in the fish with partial transgenic rescue of ift54 tp49

Expression Data
Gene:
Fish:
Anatomical Term:
Stage: Days 14-20

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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