FIGURE

Fig. 2

ID

ZDB-FIG-180118-30

Publication

Lin et al., 2017 - Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression

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Fig. 2

Genes encoding Nodal signalling components exhibited decreased or abolished expression in klf8 morphants. The majority of klf8-MO1^atg or klf8-MO2^atg -injected embryos showed decreased or abolished spaw (arrow) expression in the left lateral plate mesoderm (LPM) at the 18 s stage (a-f). The majority of klf8 morphants failed to express lft1 in the left diencephalon (arrowhead) or heart (asterisk) (g- i), lft2 in the left heart (asterisk) (j-l), and pitx2 in the left LPM (white arrow) (m-o) at the 22 s stage. Dorsal views of embryos are shown. A, absent; B, bilateral; D, decreased; L, left; R, right

Expression Data

Genes:	lft1 lft2 pitx2 spaw
Fish:	AB + MO1-klf8 AB + MO2-klf8
Knockdown Reagents:	MO1-klf8 MO2-klf8
Anatomical Terms:	lateral plate mesoderm lateral plate mesoderm left side posterior lateral plate mesoderm
Stage Range:	14-19 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-klf8 AB + MO2-klf8
Knockdown Reagents:	MO1-klf8 MO2-klf8
Observed In:	anterior lateral plate mesoderm diencephalon left side heart rudiment lateral plate mesoderm lateral plate mesoderm left side posterior lateral plate mesoderm
Stage Range:	14-19 somites to 20-25 somites

Phenotype Detail

Acknowledgments

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