Gene
lft1
- ID
- ZDB-GENE-990630-10
- Name
- lefty1
- Symbol
- lft1 Nomenclature History
- Previous Names
-
- antivin
- atv
- cb73 (1)
- ik:tdsubc_2b12
- xx:tdsubc_2b12
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 152 figures from 105 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb73 (25 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
| Domain | IPR001111 | TGF-beta, propeptide |
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Family | IPR003942 | Left- Right determination factor |
| Family | IPR015615 | Transforming growth factor-beta-related |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Left- Right determination factor | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9PW55
|
358 |
Interactions and Pathways
No data available
Plasmids
No data available