Gene

spaw

ID

ZDB-GENE-030219-1

Name

southpaw

Symbol

spaw Nomenclature History

Previous Names

ndr3 (2)
unm s457
unm t30973
unm_s457
unm_t30973

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable cytokine activity and type I activin receptor binding activity. Acts upstream of or within left/right pattern formation and regulation of BMP signaling pathway involved in heart jogging. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in anterior neural rod; cardiovascular system; diencephalon; mesoderm; and tail bud. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

188 figures from 146 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 32 figures from 21 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spaw Human Ortholog

No data available

Associated With spaw Via Experimental Models

Human Disease	Fish	Conditions	Citations
anxiety disorder	zf105Tg/zf105Tg + MO1-spaw	standard conditions	Facchin et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine