Gene

lft2

ID

ZDB-GENE-990630-11

Name

lefty2

Symbol

lft2 Nomenclature History

Previous Names

atv2 (1)
cb720 (1)
fe38b03
wu:fe38b03

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable cytokine activity. Acts upstream of or within heart field specification and mesoderm development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; cardiovascular system; central nervous system; hypoblast; and mesoderm. Orthologous to human LEFTY2 (left-right determination factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

116 figures from 91 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb720 (33 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lft2 Human Ortholog

No data available

Associated With lft2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR003942	Left- Right determination factor
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine