FIGURE

Fig. S3

ID

ZDB-FIG-150820-21

Publication

Westcot et al., 2015 - Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis

Other Figures

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Fig. S3

nrg2a mutant larvae have altered pectoral fin folds, lack swim bladders and die between 8 and 12 dpf.

(A-D) Images of live larvae at 7 dpf. (A) Wild-type pectoral fin folds (PFF) typically follow a continuous arc such that the PFF edge lies close to the body when larvae are at rest. (B) PFFs in nrg2a mutant larvae (mn0237Gt/mn0237Gt) often depart from a continuous arc shape and/or have thickened edges similar to the MFF phenotype (arrowhead). In addition, wild-type larvae have well-developed swim bladders (C), but swim bladders fail to develop in mn0237Gt/mn0237Gt mutant larvae (D, arrowhead). (E) Graphical illustration of survival rates of mn0237Gt/mn0237Gt mutant larvae (n = 104 larvae per class).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrg2a^{mn0237Gt/mn0237Gt}
Observed In:	pectoral fin fold pectoral fin fold anatomical margin whole organism
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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