FIGURE

Fig. S1

ID

ZDB-FIG-120216-69

Publication

Yoruk et al., 2012 - Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

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Fig. S1

Cranial vasculature defects can be observed in ccm3a/b morphants at 24 and 36 hpf. At 24hpf, ccm3a/b morphants (0.75 ng ccm3a/b MO) display enlarged primordial midbrain channels (PMCs), compared to wildtype embryos (yellow brackets). At 36hpf, morphant midcerebral veins, which sprout from the PMC, also appeared enlarged compared to wildtype (yellow arrows).

Expression Data

Gene:	EGFP
Fish:	s843Tg s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Anatomical Terms:	blood vessel endothelial cell cranial vasculature
Stage Range:	Prim-5 to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Observed In:	mid cerebral vein primordial midbrain channel
Stage Range:	Prim-5 to Prim-25

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 362(2), Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C., Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease, 121-131, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.