FIGURE

Fig. 7

ID

ZDB-FIG-120216-68

Publication

Yoruk et al., 2012 - Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

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Fig. 7

Injection of suboptimal doses of ccm3a/b ATG morpholino into ccm2/vtn mutants results in very severe cranial vascular defects. Gross dilations of the AceV, PrA and MsV vessels were observed upon injection of 0.25 ng ccm3a/b ATG morpholino into ccm2/vtn embryos (A–H, yellow arrows).

Expression Data

Gene:	EGFP
Fish:	ccm2^s259/s259; s843Tg s843Tg + MO1-pdcd10a,pdcd10b ccm2^s259/s259; s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Anatomical Term:	cranial vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ccm2^s259/s259; s843Tg ccm2^s259/s259; s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Observed In:	anterior cerebral vein cranial vasculature mesencephalic vein prosencephalic artery
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 362(2), Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C., Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease, 121-131, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.