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Fig. S1
Cranial vasculature defects can be observed in ccm3a/b morphants at 24 and 36 hpf. At 24hpf, ccm3a/b morphants (0.75 ng ccm3a/b MO) display enlarged primordial midbrain channels (PMCs), compared to wildtype embryos (yellow brackets). At 36hpf, morphant midcerebral veins, which sprout from the PMC, also appeared enlarged compared to wildtype (yellow arrows).
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Reprinted from Developmental Biology, 362(2), Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C., Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease, 121-131, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.