FIGURE

Fig. 3

ID

ZDB-FIG-120216-64

Publication

Yoruk et al., 2012 - Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease

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Fig. 3

The ccm3a/b cranial vasculature phenotype is specific to ccm3 function and not due to lack of blood flow. Neither santa or valentine mutant embryos display severe vascular dilations or mispatterning seen upon morpholino mediated ccm3a/b knockdown (for san, n = 21, for vtn, n = 32) (E-H) sih embryos similarly displayed no dilations in their cranial vasculature (n = 25) (I and J). Deep confocal z-stack projections (A, C, E, G and I) or z-stacks of dorsal views of the cranial vasculature (B, D, F, H and J) are shown.

Expression Data

Gene:	EGFP
Fish:	s843Tg ccm2^s259/s259; s843Tg krit1^s610/s610; s843Tg tnnt2a^b109/b109; s843Tg s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Anatomical Term:	cranial vasculature
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ccm2^s259/s259; s843Tg krit1^s610/s610; s843Tg tnnt2a^b109/b109; s843Tg s843Tg + MO1-pdcd10a,pdcd10b
Knockdown Reagent:	MO1-pdcd10a,pdcd10b
Observed In:	blood vessel endothelial cell cell projection cranial vasculature
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 362(2), Yoruk, B., Gillers, B.S., Chi, N.C., and Scott, I.C., Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease, 121-131, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.