FIGURE

Fig. 2

ID

ZDB-FIG-120127-3

Publication

Wong et al., 2012 - Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish

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Fig. 2

Endocardial and myocardial markers are reduced or absent in cyclopamine (CyA) treated embryos compared to dimethylsulfoxide (DMSO)-treated controls. (A–D) Kdrl (A,B) and cdh5 (C,D)-expression within endocardial progenitors that migrate to the midline (arrow) is greatly reduced in CyA-treated embryos (B,D) compared to controls (A,C) at the 18-somite stage. Dorsal view of the anterior region, anterior is up. (E–J) Endocardial kdrl (E,F) and NFATc1 (G-J) expression (arrows) is greatly reduced or absent in CyA-treated embryos (F,H,J) compared to controls (E,G,I) at the 24 h (E–H) and 48 h (I,J) stages. (K,L) Myocardial cmlc2 expression (arrows) is reduced in CyA-treated embryos at the 18-somite stage. (E–L) Ventral view of deyolked flat-mounted embryos, anterior is up.

Expression Data

Genes:	cdh5 kdrl myl7 nfatc1
Fish:	WT
Condition:	chemical treatment: Cyclopamine
Anatomical Terms:	endocardial precursor endocardium myocardium
Stage Range:	14-19 somites to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 361(2), Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S., Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish, 377-91, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.