Publication	Data		Fish	Anatomy
Guillon et al., 2020	Fig. 2		cdh2tm101/tm101	segmental plate broadly articulated with neural tube, abnormal segmental plate increased angle to neural tube, abnormal
	Figure 1		cdh2tm101/tm101	neural tube increased width, abnormal
	Figure 4.		cdh2tm101/tm101	segmental plate Fibronectin increased mass density, abnormal
Kesavan et al., 2020	Fig. 6		WT + CRISPR5-cdh2 + CRISPR6-cdh2	hindbrain egr2b expression spatial pattern, abnormal hindbrain otx2b expression mislocalised, abnormal midbrain otx2b expression spatial pattern, abnormal
Araya et al., 2019	Figure 5		cdh2fr7/fr7	convergent extension involved in neural plate elongation process quality, abnormal neural keel formation process quality, abnormal neural plate dorsal convergence decreased occurrence, abnormal neural plate dorsal convergence process quality, abnormal
	Figure 7		cdh2fr7/fr7	neural keel formation process quality, abnormal neural plate dorsal convergence decreased occurrence, abnormal
Guo et al., 2018	Fig. 3		cdh2m117/m117	neural rod ab1-tjp1 labeling mislocalised, abnormal neural rod ab1-tjp1 labeling spatial pattern, abnormal neural tube ab1-tjp1 labeling spatial pattern, abnormal neural tube adherens junction morphology, abnormal neural tube midsagittal plane ab1-tjp1 labeling absent, abnormal neural tube plasma membrane region ab1-tjp1 labeling mislocalised, abnormal neural tube specification of symmetry decreased occurrence, abnormal
Xing et al., 2015	Fig. 3		zf106Tg + MO1-cdh2	posterior lateral line neuromast decreased amount, abnormal posterior lateral line neuromast far from posterior lateral line neuromast, abnormal
Agarwal et al., 2014	Fig. 6		sd2Tg; y1Tg + MO1-cdh2	intersegmental vessel malformed, abnormal
Lawton et al., 2013	Fig. 5		cdh2tm101/tm101	cell migration involved in somitogenic axis elongation disrupted, abnormal tail bud adherens junction morphology, abnormal
Lu et al., 2013	Fig. 7		cdh2vu125	epiphysis split bilaterally, abnormal parapineal organ determination of left/right asymmetry in nervous system process quality, abnormal
Verstraeten et al., 2013	Fig. 3		cdh2tm101/tm101	odontogenesis delayed, abnormal tooth 3V absent, abnormal tooth 4V odontogenesis delayed, abnormal
Wanner et al., 2013	Fig. 6		ch100Tg; knu3Tg + MO1-cdh2	branchiomotor neuron decreased cellular motility, abnormal branchiomotor neuron neuron migration decreased velocity, abnormal
	Fig. 7		ch100Tg + MO1-cdh2	branchiomotor neuron decreased cellular motility, abnormal branchiomotor neuron neuron migration decreased velocity, abnormal neuron cell-cell adhesion disrupted, abnormal
	Fig. 8		ch100Tg + MO1-cdh2	branchiomotor neuron decreased cellular motility, abnormal branchiomotor neuron detached from medial longitudinal fasciculus, abnormal branchiomotor neuron neuron migration decreased velocity, abnormal neuron cell-cell adhesion disrupted, abnormal
Chalasani et al., 2011	Fig. 1		cdh2p79emcf/p79emcf	cell proliferation in hindbrain increased occurrence, abnormal
	Fig. 2		cdh2p79emcf/p79emcf	hindbrain mitotic cell cycle decreased duration, abnormal
	Fig. 4		TL + MO1-cdh2 ,   cdh2r210/r210	cell proliferation in hindbrain increased occurrence, abnormal hindbrain neural tube gli1 expression increased distribution, abnormal hindbrain neural tube gli2a expression increased distribution, abnormal hindbrain neural tube ptch2 expression increased distribution, abnormal smoothened signaling pathway increased process quality, abnormal
	Fig. 5		cdh2r210/r210	cell proliferation in hindbrain increased occurrence, abnormal
	Fig. 6		cdh2r210/r210	cilium assembly disrupted, abnormal neural tube cilium decreased length, abnormal
Zigman et al., 2011	Fig. 3		cdh2m117/m117	fourth ventricle malformed, abnormal neural rod neuroepithelial cell disorganized, abnormal secondary neural tube formation decreased process quality, abnormal
Barresi et al., 2010	Fig. 3		cdh2hi3644Tg/hi3644Tg (AB/TU)	anterior commissure commissural neuron axon guidance disrupted, abnormal anterior commissure defasciculated, abnormal cranial nerve II commissural neuron axon guidance disrupted, abnormal cranial nerve II decreased thickness, abnormal cranial nerve II defasciculated, abnormal forebrain commissural neuron axon guidance disrupted, abnormal postoptic commissure commissural neuron axon guidance disrupted, abnormal postoptic commissure defasciculated, abnormal
	Fig. 4		cdh2hi3644Tg (AB/TU)	hindbrain radial glial cell mislocalised, abnormal hindbrain radial glial cell morphology, abnormal
	Fig. 6		cdh2hi3644Tg/hi3644Tg (AB/TU)	trunk glial cell projection disorganized, abnormal trunk glial cell projection kinked, abnormal trunk glial cell projection truncated, abnormal
Beyer et al., 2010	Fig. 2		cdh2m117/m117	cornea anatomical surface structure, abnormal cornea structure, abnormal corneal epithelial cell cellular adhesivity corneal epithelial cell, abnormal corneal epithelium saccular, abnormal lens decreased size, abnormal lens perforate, abnormal lens structure, abnormal
	text only		cdh2m117/m117	corneal epithelium desmosome decreased amount, abnormal corneal stroma disorganized, abnormal
Yamaguchi et al., 2010	Fig. 1		cdh2rw707/rw707	eye proliferative region increased size, abnormal eye proliferative region mislocalised, abnormal retina disorganized, abnormal retina layer formation disrupted, abnormal retina morphogenesis in camera-type eye disrupted, abnormal
	Fig. 2		cdh2rw707/rw707	presumptive neural retina adherens junction detached from presumptive retinal pigmented epithelium, abnormal retina layer formation disrupted, abnormal
	Fig. 3		cdh2rw707/rw707; rw021Tg	exit from mitosis disrupted, abnormal eye proliferative region mislocalised, abnormal optic cup neuron decreased amount, abnormal
	Fig. 5		cdh2rw707/rw707	eye proliferative region increased size, abnormal eye proliferative region mislocalised, abnormal retina disorganized, abnormal
	Fig. 6		cdh2rw707/rw707	eye proliferative region increased size, abnormal eye proliferative region mislocalised, abnormal
Yang et al., 2009	Fig. 4		cdh2m117/m117	establishment of epithelial cell apical/basal polarity disrupted, abnormal neuroepithelial cell apical-basal polarity, abnormal
Aquilina-Beck et al., 2007	Fig. 4		cdh2p79emcf/p79emcf ,   WT + MO1-cdh2	epiphysis split, abnormal
Harrington et al., 2007	Fig. 1		cdh2p79emcf/p79emcf ,   cdh2m117/m117 ,   cdh2r210/r210 ,   cdh2m117/+; cdh2p79emcf/+	brain morphology, abnormal eye morphology, abnormal post-vent region clavate, abnormal post-vent region curved dorsal, abnormal post-vent region decreased length, abnormal post-vent region vacuolated, abnormal somite border amorphous, abnormal
	Fig. 10		cdh2p79emcf/p79emcf	paraxial mesoderm increased width, abnormal somite increased width, abnormal
	Fig. 3		cdh2m117/+ ,   cdh2p79emcf/p79emcf ,   cdh2m117/m117 ,   cdh2r210/r210	convergent extension involved in neural plate elongation disrupted, abnormal neural rod shape, abnormal
	Fig. 4		cdh2m117/m117	dorsal convergence disrupted, abnormal mesodermal cell mislocalised, abnormal neural plate increased width, abnormal paraxial mesoderm increased width, abnormal post-anal tail morphogenesis disrupted, abnormal post-vent region decreased length, abnormal somite increased width, abnormal tail bud morphology, abnormal
	Fig. 7		cdh2m117/m117	axial mesoderm mesodermal cell mislocalised, abnormal tail bud paraxial mesoderm disorganized, abnormal tail bud vacuolated, abnormal
	Fig. 8		cdh2p79emcf/p79emcf ,   cdh2m117/m117	post-vent region clavate, abnormal post-vent region curved dorsal, abnormal post-vent region decreased length, abnormal post-vent region somite morphology, abnormal post-vent region vacuolated, abnormal trunk somite morphology, abnormal
	Fig. S1		WT + MO1-cdh2	posterior neural tube T-shaped, abnormal
	text only		cdh2m117/m117	post-vent region decreased length, abnormal tail bud apoptotic, abnormal
Liu et al., 2007	Fig. 10		cdh2m117/m117 (AB)	apoptotic process increased occurrence, abnormal
	Fig. 8		cdh2m117/m117 (AB)	eye shape, abnormal
Warga et al., 2007	Fig. 1		cdh2tb8/tb8 ,   cdh2tm101/tm101	brain cell spherical, abnormal brain malformed, abnormal cell adhesion disrupted, abnormal paraxial mesoderm disorganized, abnormal paraxial mesoderm mesodermal cell spherical, abnormal post-anal tail morphogenesis disrupted, abnormal post-vent region curved dorsal, abnormal post-vent region vacuolated, abnormal spinal cord cell spherical, abnormal
	Fig. 3		cdh2tb8/tb8 ,   cdh2tm101/tm101 ,   cdh2tb8/+	tail bud increased width, abnormal
	Fig. 4		cdh2tb8/tb8 + MO1-cdh2 ,   cdh2tb8/tb8 ,   cdh2tm101/tm101 ,   cdh2tb8/+ + MO1-cdh2	somite fused with somite, abnormal whole organism morphology, abnormal
	Fig. 5		cdh2tb8/tb8 ,   cdh2tb8/+; cdh2tm101/+ ,   cdh2tm101/tm101 ,   cdh2tb8/+	anterior neural keel flat, abnormal anterior neural keel increased width, abnormal neuroectoderm malformed, abnormal posterior neural keel increased width, abnormal somite disorganized, abnormal somite fused with somite, abnormal somite increased width, abnormal
	Fig. 6		cdh2tb8/tb8 ,   cdh2tm101/tm101	paraxial mesoderm mesodermal cell spherical, abnormal
	Fig. 7		cdh2tb8/tb8	neural plate increased width, abnormal post-vent region truncated, abnormal somite condensed, abnormal somite increased width, abnormal
Babb-Clendenon et al., 2006	Fig. 1		WT + MO1-cdh2 + MO2-cdh2	hair cell anterior macula kinocilium decreased length, abnormal hair cell posterior macula kinocilium decreased length, abnormal
	Fig. 4		cdh2m117/m117 (AB)	statoacoustic (VIII) ganglion decreased size, abnormal
	Fig. 5		WT + MO1-cdh2 + MO2-cdh2	hair cell posterior macula stereocilium bundle decreased length, abnormal semicircular canal aplastic, abnormal
	Fig. 6		cdh2m117/m117 (AB)	pillar of the semicircular canal structure, abnormal semicircular canal morphogenesis disrupted, abnormal semicircular canal morphology, abnormal
Hong et al., 2006	Fig. 4		cdh2p79emcf/p79emcf	neural plate increased width, abnormal neural tube development disrupted, abnormal neural tube morphology, abnormal
Phenotype Annotation (1994-2006)	Fig. for (fr7)		cdh2fr7/fr7	brain quality, abnormal hindbrain quality, abnormal midbrain hindbrain boundary quality, abnormal midbrain quality, abnormal nervous system quality, abnormal post-vent region quality, abnormal surface structure quality, abnormal
	Fig. for (hi1389)		cdh2hi1389Tg	brain quality, abnormal retina quality, abnormal whole organism bent, abnormal
	Fig. for (hi3096)		cdh2hi3096Tg	brain quality, abnormal retina quality, abnormal whole organism bent, abnormal
	Fig. for (hi3644)		cdh2hi3644Tg	brain quality, abnormal retina quality, abnormal whole organism bent, abnormal
	Fig. for (m117)		cdh2m117/m117 (AB)	brain quality, abnormal nervous system quality, abnormal post-vent region quality, abnormal sensory system quality, abnormal whole organism shape, abnormal
	Fig. for (p79emcf)		cdh2p79emcf/p79emcf	hindbrain quality, abnormal peripheral neuron quality, abnormal trunk musculature quality, abnormal
	Fig. for (r210)		cdh2r210/r210	brain quality, abnormal eye quality, abnormal hindbrain quality, abnormal midbrain hindbrain boundary quality, abnormal midbrain quality, abnormal nervous system quality, abnormal post-vent region quality, abnormal sensory system quality, abnormal surface structure quality, abnormal
	Fig. for (rw95)		cdh2rw95/rw95	retina quality, abnormal
	Fig. for (tb8)		cdh2tb8/tb8	brain quality, abnormal gastrulation with mouth forming second quality, abnormal nervous system quality, abnormal post-vent region quality, abnormal somite quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tc248c)		cdh2tc248c/tc248c	brain quality, abnormal hindbrain quality, abnormal nervous system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tg1a)		cdh2tg1a/tg1a	brain quality, abnormal hindbrain quality, abnormal nervous system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tg299b)		cdh2tg299b/tg299b	brain quality, abnormal hindbrain quality, abnormal nervous system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tj250a)		cdh2tj250a/tj250a	brain quality, abnormal hindbrain quality, abnormal nervous system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tm101)		cdh2tm101/tm101	brain quality, abnormal hindbrain quality, abnormal nervous system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (wi440)		cdh2wi440Tg	brain quality, abnormal hindbrain quality, abnormal
Amsterdam et al., 2004	text only		cdh2hi1389Tg/hi1389Tg	brain morphology, abnormal brain surface feature shape, abnormal head decreased size, abnormal head surface feature shape, abnormal trunk bent, abnormal trunk decreased thickness, abnormal
Cortés et al., 2003	Fig. 4		cdh2tm101/tm101	muscle cell migration arrested, abnormal slow muscle cell myofibril bent, abnormal slow muscle cell myofibril elongated, abnormal
Erdmann et al., 2003	Fig. 1		cdh2r210/r210	brain disoriented, abnormal eye fused with brain, abnormal lens decreased size, abnormal lens disorganized, abnormal lens disoriented, abnormal lens mislocalised, abnormal maintenance of epithelial cell apical/basal polarity disrupted, abnormal retina disorganized, abnormal retinal ganglion cell layer mislocalised, abnormal retinal inner plexiform layer structure, abnormal retinal outer plexiform layer structure, abnormal retinal pigmented epithelium position, abnormal
	Fig. 2		cdh2r210/r210	maintenance of epithelial cell apical/basal polarity disrupted, abnormal retinal ganglion cell layer mislocalised, abnormal retinal inner plexiform layer structure, abnormal retinal outer plexiform layer structure, abnormal retinal pigmented epithelium position, abnormal
	Fig. 3		cdh2r210/r210	whole organism photoreceptor outer segment decreased length, abnormal
	text only		cdh2r210/r210	whole organism organismal quality, abnormal
Liu et al., 2003	Fig. 3		WT + MO1-cdh2 + MO2-cdh2	cranial nerve II defasciculated, abnormal fourth ventricle cell mislocalised, abnormal fourth ventricle increased size, abnormal hindbrain disorganized, abnormal midbrain disorganized, abnormal midbrain fourth ventricle mislocalised anteriorly, abnormal pectoral fin development disrupted, abnormal
	Fig. 4		WT + MO1-cdh2 + MO2-cdh2	pectoral fin bud cartilage element absent, abnormal pectoral fin bud cartilage element disorganized, abnormal pectoral fin development disrupted, abnormal
Lele et al., 2002	Fig. 1		cdh2fr7/fr7	dorsal fin fold posterior side decreased size, abnormal dorsal fin fold posterior side split medially, abnormal fourth ventricle increased size, abnormal hindbrain disorganized, abnormal hindbrain dorsal region has extra parts of type neuron, abnormal hindbrain neural keel shape, abnormal midbrain disorganized, abnormal midbrain dorsal region has extra parts of type neuron, abnormal midbrain hindbrain boundary absent, abnormal neural rod increased width, abnormal neuroepithelial cell displaced to fourth ventricle, abnormal
	Fig. 2		cdh2fr7/fr7	cell-cell adhesion disrupted, abnormal hindbrain morphology, abnormal hindbrain neural tube neuroepithelial cell morphology, abnormal neuroepithelial cell morphology, abnormal
	Fig. 3		WT + MO1-cdh2	fourth ventricle increased size, abnormal hindbrain disorganized, abnormal midbrain disorganized, abnormal neuroepithelial cell displaced to fourth ventricle, abnormal
	Fig. 4		cdh2fr7/fr7	alar plate midbrain region separated from basal plate midbrain region, abnormal neural tube formation decreased process quality, abnormal
	Fig. 5		cdh2r210/r210 ,   cdh2fr7/fr7	hindbrain interneuron irregular spatial pattern, abnormal hindbrain interneuron mislocalised, abnormal hindbrain motor neuron mislocalised anteriorly, abnormal hindbrain motor neuron mislocalised dorsally, abnormal Mauthner neuron irregular spatial pattern, abnormal
	Fig. 6		cdh2fr7/fr7	commissural neuron axon guidance disrupted, abnormal hindbrain dorsal region has extra parts of type neuron, abnormal midbrain dorsal region has extra parts of type neuron, abnormal optic chiasma development disrupted, abnormal spinal cord motor neuron axon guidance disrupted, abnormal
	Fig. 7		cdh2fr7/fr7	cell proliferation in hindbrain increased occurrence, abnormal cell proliferation in midbrain increased occurrence, abnormal neural tube cell increased amount, abnormal
Hammerschmidt et al., 1996	text only		cdh2tb8/tb8	axis condensed, abnormal convergent extension involved in axis elongation disrupted, abnormal somite morphology, abnormal tail bud increased width, abnormal trunk increased width, abnormal whole organism viability, abnormal
Jiang et al., 1996	Fig. 6		cdh2tj250a/tj250a ,   cdh2tg1a/tg1a ,   cdh2tm101/tm101	cell filopodium present, abnormal fourth ventricle composition, abnormal hindbrain decreased thickness, abnormal hindbrain neural keel umbonate, abnormal hindbrain surface feature shape, abnormal ventricular system composition, abnormal
	Fig. 7		cdh2tj250a/tj250a	hindbrain neuron disorganized, abnormal spinal cord interneuron disorganized, abnormal
	Fig. 8		cdh2tj250a/tj250a	hindbrain interneuron disorganized, abnormal Mauthner neuron displaced to rhombomere posterior region, abnormal Mauthner neuron mislocalised, abnormal
	Table 1		cdh2tg299b/tg299b ,   cdh2tj250a/tj250a ,   cdh2tg1a/tg1a ,   cdh2tm101/tm101 ,   cdh2tc248c/tc248c	hindbrain cell aggregated, abnormal hindbrain cell loose, abnormal midbrain cell loose, abnormal whole organism viability, abnormal
Malicki et al., 1996	Fig. 2		cdh2m117/m117 (AB)	brain disorganized, abnormal brain shape, abnormal eye pigmentation disrupted, abnormal melanocyte differentiation delayed, abnormal post-anal tail morphogenesis disrupted, abnormal post-vent region morphology, abnormal retinal pigmented epithelium poorly differentiated, abnormal whole organism curved ventral, abnormal
	Fig. 3		cdh2m117/m117 (AB)	retina layer formation disrupted, abnormal retinal inner plexiform layer patchy, abnormal retinal neural layer disorganized, abnormal retinal outer plexiform layer patchy, abnormal
	Table 1		cdh2m117/m117 (AB)	blood circulation disrupted, abnormal
Trowe et al., 1996	Fig. 8		cdh2tm101/tm101	eye decreased size, abnormal optic tectum decreased size, abnormal