PUBLICATION
Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome
- Authors
- Cortés, F., Daggett, D., Bryson-Richardson, R.J., Neyt, C., Maule, J., Gautier, P., Hollway, G.E., Keenan, D., and Currie, P.D.
- ID
- ZDB-PUB-031217-2
- Date
- 2003
- Source
- Developmental Cell 5(6): 865-876 (Journal)
- Registered Authors
- Bryson-Richardson, Robert, Currie, Peter D., Daggett, Dave, Maule, John, Neyt, Christine
- Keywords
- none
- MeSH Terms
-
- Animals
- Cadherins/genetics*
- Cadherins/metabolism
- Cell Adhesion/physiology
- Cell Movement/physiology*
- Gene Expression Regulation, Developmental
- Muscle Fibers, Slow-Twitch/cytology*
- Muscle Fibers, Slow-Twitch/physiology*
- Muscle, Skeletal/cytology*
- Muscle, Skeletal/embryology*
- Muscle, Skeletal/physiology
- Mutagenesis, Site-Directed
- Zebrafish
- PubMed
- 14667409 Full text @ Dev. Cell
Citation
Cortés, F., Daggett, D., Bryson-Richardson, R.J., Neyt, C., Maule, J., Gautier, P., Hollway, G.E., Keenan, D., and Currie, P.D. (2003) Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome. Developmental Cell. 5(6):865-876.
Abstract
Differential cell adhesion has long been postulated to play important roles in cell sorting and cell migration; however, these roles have been studied in very few specific contexts. Thus, the deployment and utility of differential adhesion as a developmental mechanism remains somewhat unclear. Cortes et al. find that a dynamic wave of characteristic cadherin expression moves through the
developing somite, and is required to guide adaxial (presumptive slow twitch) muscle cells across the entire width of the myotome. This work establishes important principles underlying the contribution of differential cell adhesion to vertebrate morphogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping