FIGURE

Figure 1.

ID
ZDB-FIG-240206-46
Publication
Wright et al., 2024 - Zebrafish tsc1 and cxcl12a increase susceptibility to mycobacterial infection
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Figure 1.

Infection-induced miR-126 expression alters bacterial burden.

(A) Expression of miR-126 after M. marinum infection analysed by RT-qPCR at 1 and 3 dpi relative to uninfected embryos. (B) Expression of miR-126 in uninfected and infected, antagomir-injected (miR-126 knockdown), and scramble-injected embryos. (C) Representative images of M. marinum infection at 3 dpi in scramble control and miR-126 knockdown embryos. Scale bar represents 200 μm. (D)M. marinum burden in miR-126 knockdown embryos at 1 and 3 dpi. (E) Expression of miR-126 in uninfected and infected gRNA/Cas9-injected embryos at 5 dpi. (F)M. marinum burden in miR-126 crispant embryos at 5 dpi. Data information: each data point represents a single measurement, with the mean and SEM shown. For RT-qPCR analysis, each data point represents 10 embryos and contains three biological replicates. Bacterial burden analysis data points represent individual embryos (n = 40–50 embryos per group) and are representative of two experimental replicates.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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