FIGURE

Fig. 5.

ID

ZDB-FIG-230420-82

Publication

Snodgrass et al., 2023 - Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia

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Fig. 5.

Combined low-dose mTOR and MEK inhibition prevents abnormal trunk vasculature and excess kugel formation in eng^mu130 zebrafish embryos. (A-C) Neither 2 µM rapamycin (RAP) nor 7.5 µM PD0325901 (PD0) alters the vascular phenotype of eng^mu130 mutants, but combined treatment resulted in normalised DA and PCV diameters, as well as reduced kugel formation in eng^mu130 zebrafish embryos. *P<0.05, ***P<0.001, ****P<0.0001; ns, not significant (two-way ANOVA with Tukey post-hoc test, 10-14 animals/group).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s916Tg eng^mu130/mu130; s916Tg
Condition:	chemical treatment by environment: PD 0325901
Observed In:	blood vessel endothelial cell plasma membrane bounded cell projection brain vasculature blood vessel endothelial cell dorsal aorta posterior cardinal vein
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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