FIGURE

Fig. 1.

ID

ZDB-FIG-230420-58

Publication

Snodgrass et al., 2023 - Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia

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Fig. 1.

Adult eng^mu130 fish display cutaneous and retinal vascular malformations similar to those in patients with hereditary haemorrhagic telangiectasia and an enlarged heart. (A) Adult 5- to 6-month-old eng^mu130 zebrafish display cutaneous vascular malformations (black arrows). Scale bars: 1 cm. (B) Representative eng^mu130 and wild-type (WT) hearts (n=5/group). Scale bars: 500 μm. (C) Body weight of adult WT and eng^mu130 zebrafish. (D) Cardiac ventricle weight/body weight of WT and eng^mu130 zebrafish. (E) Fluorescent micrographs of whole-mount retinae from Tg(kdrl:Hsa.HRAS-mCherry)^s916 zebrafish, showing abnormal vessel communications in eng^mu130 (white arrowheads). Scale bars: 500 μm. (F) Schematic diagram of a 5- to 6-month-old zebrafish retinal vasculature. Figure created with BioRender. (G) Number of retinal vascular branches in WT and eng^mu130 homozygous siblings. (H) Optic artery diameter in WT and eng^mu130 homozygous siblings. (I) Inter-capillary distance in WT and eng^mu130 homozygous siblings. **P<0.01, ****P<0.0001 (unpaired two-tailed Student's t-test, 8-10 animals/group).

Expression Data

Gene:	mCherry
Fish:	s916Tg eng^mu130/mu130; s916Tg
Anatomical Term:	ocular blood vessel plasma membrane
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eng^mu130/mu130 eng^mu130/mu130; s916Tg
Observed In:	heart integument vasculature optic artery whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

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