FIGURE

Fig. 2.

ID
ZDB-FIG-230420-79
Publication
Snodgrass et al., 2023 - Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia
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Fig. 2.

engmu130 mutant embryos have increased basilar artery diameter and increased number of endothelial kugeln. (A) Representative maximum-intensity projection of Tg(kdrl:Hsa.HRAS-mCherry)s916 zebrafish brain vasculature at 72 hpf. Black arrowheads indicate individual kugeln. Scale bars: 150 μm/50 μm (inset). Three-dimensional reconstruction of the same image shown in green is on the right. (B) Representative maximum-intensity projection of the basilar artery (BA) at 72 hpf. Black arrowheads indicate individual kugeln. White bars indicate where diameter of the BA was measured. Scale bar: 50 μm. Three-dimensional reconstructions of the same images shown in green are on the right. (C) BA diameter in engmu130 mutants and WT siblings (unpaired two-tailed Student's t-test, 10-12 animals/group). (D) eng mutation did not alter endothelial cell (EC) number in the BA (unpaired two-tailed Student's t-test, 10-12 animals/group). (E) Kugel number per animal was increased in engmu130 mutants at 52 and 74 h post fertilisation (hpf) but not at 100 hpf. *P<0.05; ns, not significant (Mann–Whitney U-test, 8-27 animals/group).

Expression Data
Gene:
Fish:
Anatomical Term:
Stage: Protruding-mouth

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage Range: Long-pec to Day 4

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.