ZFIN Image: Snodgrass et al., 2023, Fig. 1.

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Figure Caption

Fig. 1.

Adult eng^mu130 fish display cutaneous and retinal vascular malformations similar to those in patients with hereditary haemorrhagic telangiectasia and an enlarged heart. (A) Adult 5- to 6-month-old eng^mu130 zebrafish display cutaneous vascular malformations (black arrows). Scale bars: 1 cm. (B) Representative eng^mu130 and wild-type (WT) hearts (n=5/group). Scale bars: 500 μm. (C) Body weight of adult WT and eng^mu130 zebrafish. (D) Cardiac ventricle weight/body weight of WT and eng^mu130 zebrafish. (E) Fluorescent micrographs of whole-mount retinae from Tg(kdrl:Hsa.HRAS-mCherry)^s916 zebrafish, showing abnormal vessel communications in eng^mu130 (white arrowheads). Scale bars: 500 μm. (F) Schematic diagram of a 5- to 6-month-old zebrafish retinal vasculature. Figure created with BioRender. (G) Number of retinal vascular branches in WT and eng^mu130 homozygous siblings. (H) Optic artery diameter in WT and eng^mu130 homozygous siblings. (I) Inter-capillary distance in WT and eng^mu130 homozygous siblings. **P<0.01, ****P<0.0001 (unpaired two-tailed Student's t-test, 8-10 animals/group).

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.