FIGURE

FIGURE 5

ID

ZDB-FIG-220924-5

Publication

Wareham et al., 2022 - Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

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FIGURE 5

Adamts10 MO reduces pSmad3-Mediated TGFβ family signaling in zebrafish retinae. Representative fluorescent images of an uninjected (A) and adamts10 MO-injected (B)Tg(12xSBE:EGFP) embryo at 48 hpf showing fluorescence reporting of active pSmad3-mediated signaling in the retina (white arrows), brain (magenta arrows) and lens (cyan arrows, scale = 250 µm). Normalized integrated fluorescence density of uninjected, and adamts10 MO-injected Tg(12xSBE:EGFP) embryos at 48 hpf [(C), n = 21 and n = 11, respectively, ****p < 0.0001; Welch’s t-test].

Expression Data

Gene:	EGFP
Fish:	ia16Tg ia16Tg + MO1-adamts10
Knockdown Reagent:	MO1-adamts10
Anatomical Terms:	brain lens retina
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ia16Tg + MO1-adamts10
Knockdown Reagent:	MO1-adamts10
Observed In:	lens retina
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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